Sodium iodide is a vital inorganic compound with important applications across medicine, industry, and scientific research. Its distinctive chemical characteristics and wide-ranging uses have made it an essential substance in various fields. In this detailed overview, we will examine all aspects of sodium iodide, including its chemical structure, properties, methods of preparation, applications, safety considerations, and its significance in industrial processes.
Introduction to Sodium Iodide
Sodium iodide (NaI) is an ionic compound consisting of sodium (Na⁺) and iodide (I⁻) ions. It usually occurs as a white crystalline solid that dissolves readily in water and alcohol. It serves as an important source of iodine it carrying notable nutritional and medical importance. While it closely resembles table salt in appearance, its chemical reactivity and applications are distinctly different.
Molecular Structure and Formula
- Chemical Formula: NaI
- Molar Mass: 149.89 g/mol
- Appearance: White crystalline solid
- Crystal Structure: Cubic lattice
- Ionic Nature: Strong ionic bond between sodium cations and iodide anions
The strong ionic interaction between sodium and iodide ions gives sodium iodide its high solubility in polar solvents like water, making it easy to use in biological and industrial processes.
Physical and Chemical Properties of Sodium Iodide

Sodium iodide exhibits several important physical and chemical properties that make it valuable across diverse applications:
- Melting Point: 661 °C (1222 °F)
- Boiling Point: 1304 °C (2379 °F)
- Density: 3.67 g/cm³
- Solubility: Highly soluble in water, ethanol, methanol, and acetone.
- Color: White, but turns brownish on exposure to air due to oxidation of iodide ions to iodine.
Reactivity
- Reacts with strong oxidizing agents to release elemental iodine.
- Sensitive to light and air; often stored with stabilizers.
- In acidic environments, sodium iodide functions as a reducing agent, leading to the formation of iodine.
Preparation of Sodium Iodide
Sodium iodide is prepared through neutralization or direct reaction processes. Common methods include:
- Reaction of Hydroiodic Acid with Sodium Hydroxide HI+NaOH→NaI+H2OHI + NaOH → NaI + H₂O
- Direct Reaction of Iodine with Sodium Metal in Dry Ether 2Na+I2→2NaI2Na + I₂ → 2NaI
- Industrial Production
Large-scale production typically involves treating sodium carbonate with hydroiodic acid, followed by crystallization and purification.
Applications of Sodium Iodide
1. Medical Applications
Sodium iodide plays a vital role in healthcare:
- Iodine Supplementation: Used to prevent and treat iodine deficiency and goiter.
- Contrast Agents: Sodium iodide is a component in radiographic contrast materials.
2. Industrial Uses
- Photography: Historically used in photographic emulsions.
- Organic Synthesis: Serves as a reagent in Finkelstein reactions to prepare alkyl iodides.
- Catalysis: Employed as a catalyst and stabilizer in chemical processes.
- Scintillation Detectors: Sodium iodide crystals doped with thallium [NaI(Tl)] are used as scintillators in radiation detection, especially in gamma-ray spectroscopy.
3. Food and Nutrition

- Added in small amounts to table salt to produce iodized salt, preventing iodine deficiency in populations.
- Used in veterinary medicine for nutritional supplementation in livestock.
4. Laboratory Applications
- Halide Exchange Reactions: Used in organic chemistry for the substitution of halides.
- Analytical Chemistry: Helps in titrations and qualitative analysis of iodine-containing compounds.
Safety and Handling of Sodium Iodide
While sodium iodide offers many advantages, it must be handled cautiously because of its possible health and environmental hazards.
Health Hazards
- Excessive ingestion can lead to iodism, with symptoms such as headache, metallic taste, and skin rashes.
- Chronic exposure may affect thyroid function.
- Radioactive forms (NaI-131) must be handled with strict radiation safety protocols.
Storage Precautions
- Store in airtight, light-resistant containers to prevent decomposition.
- Keep away from heat, moisture, and strong oxidizing agents.
- Use protective gloves, goggles, and lab coats when handling.
Environmental Impact
Sodium iodide is generally safe in controlled amounts, but must be regulated in large-scale disposal:
- Water Solubility: Can lead to accumulation in aquatic environments.
- Radioactive Isotopes: Require strict waste management to avoid contamination.

Proper disposal and adherence to environmental safety regulations are essential when dealing with sodium iodide in industrial or medical applications.
Conclusion
Sodium iodide is a versatile compound with immense importance in medicine, industry, food, and research. From preventing iodine deficiency to treating thyroid diseases and serving as a key component in radiation detection, sodium iodide continues to be a critical compound in modern science and technology. Its wide-ranging applications highlight its significance, while careful handling ensures safety in both medical and industrial settings.
What are the main uses of sodium iodide?
How is sodium iodide prepared?
Why is sodium iodide important in nuclear medicine?
Is sodium iodide safe to use?
What are the physical properties of sodium iodide?
What is sodium iodide?
Introduction
Sodium iodide (NaI) is an ionic compound consisting of sodium (Na⁺) and iodide (I⁻) ions. It usually occurs as a white crystalline solid that dissolves readily in water and alcohol. Serving as an important source of iodine, it carries notable nutritional and medical importance. While it closely resembles table salt in appearance, its chemical reactivity and applications are distinctly different.
Molecular Structure and Formula
Chemical Formula: NaI
Molar Mass: 149.89 g/mol
Appearance: White crystalline solid
Crystal Structure: Cubic lattice
Ionic Nature: Strong ionic bond between sodium cations and iodide anions
The strong ionic interaction between sodium and iodide ions gives sodium iodide its high solubility in polar solvents like water, making it easy to use in biological and industrial processes.
Physical and Chemical Properties
Sodium iodide exhibits several important physical and chemical properties that make it valuable across diverse applications:
Melting Point: 661 °C (1222 °F)
Boiling Point: 1304 °C (2379 °F)
Density: 3.67 g/cm³
Solubility: Highly soluble in water, ethanol, methanol, and acetone.
Color: White, but turns brownish on exposure to air due to oxidation of iodide ions to iodine.
Reactivity
Reacts with strong oxidizing agents to release elemental iodine.
Sensitive to light and air; often stored with stabilizers.
In acidic environments, sodium iodide functions as a reducing agent, leading to the formation of iodine.
Preparation
Sodium iodide is prepared through neutralization or direct reaction processes. Common methods include:
Reaction of Hydroiodic Acid with Sodium Hydroxide HI+NaOH→NaI+H2OHI + NaOH → NaI + H₂O
Direct Reaction of Iodine with Sodium Metal in Dry Ether 2Na+I2→2NaI2Na + I₂ → 2NaI
Industrial Production
Large-scale production typically involves treating sodium carbonate with hydroiodic acid, followed by crystallization and purification.
Applications
1. Medical Applications
Sodium iodide plays a vital role in healthcare:
Iodine Supplementation: Used to prevent and treat iodine deficiency and goiter.
Contrast Agents: Sodium iodide is a component in radiographic contrast materials.
2. Industrial Uses
Photography: Historically used in photographic emulsions.
Organic Synthesis: Serves as a reagent in Finkelstein reactions to prepare alkyl iodides.
Catalysis: Employed as a catalyst and stabilizer in chemical processes.
Scintillation Detectors: Sodium iodide crystals doped with thallium [NaI(Tl)] are used as scintillators in radiation detection, especially in gamma-ray spectroscopy.
3. Food and Nutrition
Added in small amounts to table salt to produce iodized salt, preventing iodine deficiency in populations.
Used in veterinary medicine for nutritional supplementation in livestock.
4. Laboratory Applications
Halide Exchange Reactions: Used in organic chemistry for the substitution of halides.
Analytical Chemistry: Helps in titrations and qualitative analysis of iodine-containing compounds.
Safety and Handling of Sodium Iodide
While sodium iodide offers many advantages, it must be handled cautiously because of its possible health and environmental hazards.
Health Hazards
Excessive ingestion can lead to iodism, with symptoms such as headache, metallic taste, and skin rashes.
Chronic exposure may affect thyroid function.
Radioactive forms (NaI-131) must be handled with strict radiation safety protocols.
Storage Precautions
Store in airtight, light-resistant containers to prevent decomposition.
Keep away from heat, moisture, and strong oxidizing agents.
Use protective gloves, goggles, and lab coats when handling.
Environmental Impact
Sodium iodide is generally safe in controlled amounts, but must be regulated in large-scale disposal:
Water Solubility: Can lead to accumulation in aquatic environments.
Radioactive Isotopes: Require strict waste management to avoid contamination.
Proper disposal and adherence to environmental safety regulations are essential when dealing with sodium iodide in industrial or medical applications.
Conclusion
It is a versatile compound with immense importance in medicine, industry, food, and research. From preventing iodine deficiency to treating thyroid diseases and serving as a key component in radiation detection, sodium iodide continues to be a critical compound in modern science and technology. Its wide-ranging applications highlight its significance, while careful handling ensures safety in both medical and industrial settings.
What is sodium iodide (NaI)?
Introduction
Sodium iodide (NaI) is an ionic compound consisting of sodium (Na⁺) and iodide (I⁻) ions. It usually occurs as a white crystalline solid that dissolves readily in water and alcohol. Serving as an important source of iodine, it carries notable nutritional and medical importance. While it closely resembles table salt in appearance, its chemical reactivity and applications are distinctly different.
Molecular Structure and Formula
Chemical Formula: NaI
Molar Mass: 149.89 g/mol
Appearance: White crystalline solid
Crystal Structure: Cubic lattice
Ionic Nature: Strong ionic bond between sodium cations and iodide anions
The strong ionic interaction between sodium and iodide ions gives sodium iodide its high solubility in polar solvents like water, making it easy to use in biological and industrial processes.
Physical and Chemical Properties
Sodium iodide exhibits several important physical and chemical properties that make it valuable across diverse applications:
Melting Point: 661 °C (1222 °F)
Boiling Point: 1304 °C (2379 °F)
Density: 3.67 g/cm³
Solubility: Highly soluble in water, ethanol, methanol, and acetone.
Color: White, but turns brownish on exposure to air due to oxidation of iodide ions to iodine.
Reactivity
Reacts with strong oxidizing agents to release elemental iodine.
Sensitive to light and air; often stored with stabilizers.
In acidic environments, sodium iodide functions as a reducing agent, leading to the formation of iodine.
Preparation
Sodium iodide is prepared through neutralization or direct reaction processes. Common methods include:
Reaction of Hydroiodic Acid with Sodium Hydroxide HI+NaOH→NaI+H2OHI + NaOH → NaI + H₂O
Direct Reaction of Iodine with Sodium Metal in Dry Ether 2Na+I2→2NaI2Na + I₂ → 2NaI
Industrial Production
Large-scale production typically involves treating sodium carbonate with hydroiodic acid, followed by crystallization and purification.
Applications
1. Medical Applications
Sodium iodide plays a vital role in healthcare:
Iodine Supplementation: Used to prevent and treat iodine deficiency and goiter.
Contrast Agents: Sodium iodide is a component in radiographic contrast materials.
2. Industrial Uses
Photography: Historically used in photographic emulsions.
Organic Synthesis: Serves as a reagent in Finkelstein reactions to prepare alkyl iodides.
Catalysis: Employed as a catalyst and stabilizer in chemical processes.
Scintillation Detectors: Sodium iodide crystals doped with thallium [NaI(Tl)] are used as scintillators in radiation detection, especially in gamma-ray spectroscopy.
3. Food and Nutrition
Added in small amounts to table salt to produce iodized salt, preventing iodine deficiency in populations.
Used in veterinary medicine for nutritional supplementation in livestock.
4. Laboratory Applications
Halide Exchange Reactions: Used in organic chemistry for the substitution of halides.
Analytical Chemistry: Helps in titrations and qualitative analysis of iodine-containing compounds.
Safety and Handling of Sodium Iodide
While sodium iodide offers many advantages, it must be handled cautiously because of its possible health and environmental hazards.
Health Hazards
Excessive ingestion can lead to iodism, with symptoms such as headache, metallic taste, and skin rashes.
Chronic exposure may affect thyroid function.
Radioactive forms (NaI-131) must be handled with strict radiation safety protocols.
Storage Precautions
Store in airtight, light-resistant containers to prevent decomposition.
Keep away from heat, moisture, and strong oxidizing agents.
Use protective gloves, goggles, and lab coats when handling.
Environmental Impact
Sodium iodide is generally safe in controlled amounts, but must be regulated in large-scale disposal:
Water Solubility: Can lead to accumulation in aquatic environments.
Radioactive Isotopes: Require strict waste management to avoid contamination.
Proper disposal and adherence to environmental safety regulations are essential when dealing with sodium iodide in industrial or medical applications.
Conclusion
It is a versatile compound with immense importance in medicine, industry, food, and research. From preventing iodine deficiency to treating thyroid diseases and serving as a key component in radiation detection, sodium iodide continues to be a critical compound in modern science and technology. Its wide-ranging applications highlight its significance, while careful handling ensures safety in both medical and industrial settings.
What industries use sodium iodide?
What are the applications of NaI?
1. Medical Applications
It plays a vital role in healthcare:
Iodine Supplementation: Used to prevent and treat iodine deficiency and goiter.
Contrast Agents: It is a component in radiographic contrast materials.
2. Industrial Uses
Photography: Historically used in photographic emulsions.
Organic Synthesis: Serves as a reagent in Finkelstein reactions to prepare alkyl iodides.
Catalysis: Employed as a catalyst and stabilizer in chemical processes.
Scintillation Detectors: Sodium iodide crystals doped with thallium [NaI(Tl)] are used as scintillators in radiation detection, especially in gamma-ray spectroscopy.
3. Food and Nutrition
Added in small amounts to table salt to produce iodized salt, preventing iodine deficiency in populations.
Used in veterinary medicine for nutritional supplementation in livestock.
4. Laboratory Applications
Halide Exchange Reactions: Used in organic chemistry for the substitution of halides.
Analytical Chemistry: Helps in titrations and qualitative analysis of iodine-containing compounds.
Safety and Handling of Sodium Iodide
While NaI offers many advantages, it must be handled cautiously because of its possible health and environmental hazards.
Health Hazards
Excessive ingestion can lead to iodism, with symptoms such as headache, metallic taste, and skin rashes.
Chronic exposure may affect thyroid function.
Radioactive forms (NaI-131) must be handled with strict radiation safety protocols.
Storage Precautions
Store in airtight, light-resistant containers to prevent decomposition.
Keep away from heat, moisture, and strong oxidizing agents.
Use protective gloves, goggles, and lab coats when handling.
Environmental Impact
Sodium iodide is generally safe in controlled amounts, but must be regulated in large-scale disposal:
Water Solubility: Can lead to accumulation in aquatic environments.
Radioactive Isotopes: Require strict waste management to avoid contamination.
Proper disposal and adherence to environmental safety regulations are essential when dealing with sodium iodide in industrial or medical applications.
Conclusion
Sodium iodide is a versatile compound with immense importance in medicine, industry, food, and research. From preventing iodine deficiency to treating thyroid diseases and serving as a key component in radiation detection, sodium iodide continues to be a critical compound in modern science and technology. Its wide-ranging applications highlight its significance, while careful handling ensures safety in both medical and industrial settings.