Sodium thiosulfate is a versatile chemical compound widely recognized for its diverse applications in industries, laboratories, and medicine. Known by its chemical formula Na₂S₂O₃, this crystalline substance has significant roles ranging from water treatment and photography to medical treatments. In this comprehensive guide, we explore the properties, preparation, uses, benefits, and safety considerations of sodium thiosulfate.
Introduction to Sodium Thiosulfate
Sodium thiosulfate is an inorganic salt composed of sodium, sulfur, and oxygen. It commonly appears as colorless, odorless crystals that dissolve easily in water. Its pentahydrate form (Na₂S₂O₃·5H₂O) is the most stable and widely used.

This compound is known for its ability to neutralize toxins, reduce chlorine levels, and act as a powerful reducing agent. It is often referred to as “hypo” in the field of photography, where it serves as a fixer for developing films and photographs.
Chemical Properties of Sodium Thiosulfate
Understanding the chemical nature of sodium thiosulfate is essential for its wide-scale applications:
- Molecular formula: Na₂S₂O₃
- Molar mass: 158.11 g/mol (anhydrous), 248.18 g/mol (pentahydrate)
- Appearance: Transparent, colorless crystals
- Solubility: Highly soluble in water, slightly soluble in alcohol
- Melting point: 48 °C (pentahydrate loses water of crystallization)
- pH: Neutral to slightly alkaline in solution
One of its most important reactions is with iodine, where it reduces iodine to iodide, making it useful in titrimetric analysis in chemistry.
Preparation of Sodium Thiosulfate
Sodium thiosulfate is typically prepared through industrial processes, involving the reaction of sodium sulfite with sulfur.
Equation:
Na₂SO₃ + S → Na₂S₂O₃
Another method involves the reaction of sodium hydroxide with sulfur dioxide in the presence of sulfur. These methods ensure large-scale production to meet industrial and medical demand.
Uses of Sodium Thiosulfate
Sodium thiosulfate has numerous applications due to its chemical reactivity and safety profile. Some of the most important uses include:
1. Medical Applications
- Used as an antidote for cyanide poisoning by converting toxic cyanide into harmless thiocyanate, which is excreted through urine.
- Employed in the treatment of calciphylaxis, a rare but serious condition in patients with chronic kidney disease.
- Acts as a chelating agent to detoxify the body from heavy metals like arsenic and mercury.
- Sometimes used in dermatology to treat fungal skin infections.
2. Water Treatment
- Neutralizes excess chlorine in drinking water and swimming pools.
- Removes residual disinfectants after water treatment processes.
- Plays a role in aquarium maintenance by detoxifying harmful chlorine and chloramine.
3. Analytical Chemistry

- Widely used in iodometric titrations due to its reducing property.
- Helps determine the amount of oxidizing agents present in a solution.
4. Industrial Applications
- Functions as a fixer in photography, stabilizing photographic images by dissolving unreacted silver halide.
- Utilized in the leaching of gold and silver in mining industries.
- Serves as a dechlorinating agent in the textile and paper industries.
- Prevents bleaching damage in fabrics during processing.
5. Food Industry
- It acts as a preservative and helps neutralize excess chlorine in food processing.
Benefits of Sodium Thiosulfate
- Versatility: Its ability to act as a reducing, detoxifying, and stabilizing agent makes it valuable across sectors.
- Safety: Compared to many chemicals, sodium thiosulfate has a relatively low toxicity profile when used correctly.
- Cost-Effectiveness: Its wide availability and affordability make it a preferred choice in industries.
- Medical Importance: Life-saving in cases of poisoning and kidney-related complications.
Health and Safety Considerations
While sodium thiosulfate is generally safe, it should be handled with care:
- Inhalation: Dust may cause mild irritation of the respiratory tract.
- Skin contact: Can cause slight irritation in sensitive individuals.
- Ingestion: Considered safe in medical doses but may lead to gastrointestinal discomfort if consumed in large amounts.
- Storage: Keep in a cool, dry place away from moisture and strong acids.
Always follow standard laboratory safety guidelines and consult a professional before using sodium thiosulfate for medical purposes.
Environmental Impact
Sodium thiosulfate is relatively safe for the environment:
- Helps in neutralizing harmful chemicals in wastewater.
- Used in aquariums to make water safe for fish.
- Biodegradable and breaks down into harmless byproducts.
However, large uncontrolled releases into water systems should be avoided to maintain ecological balance.

Conclusion
Sodium thiosulfate is a multi-functional chemical with profound importance in medicine, industry, water treatment, and environmental safety. Its unique ability to detoxify, reduce, and stabilize makes it indispensable in modern science and technology. From saving lives in medical emergencies to purifying drinking water and preserving photographs, sodium thiosulfate stands out as a compound of immense value.
What is Sodium Thiosulfate?
Introduction to Sodium Thiosulfate
Sodium thiosulfate is an inorganic salt composed of sodium, sulfur, and oxygen. It commonly appears as colorless, odorless crystals that dissolve easily in water. Its pentahydrate form (Na₂S₂O₃·5H₂O) is the most stable and widely used.
This compound is known for its ability to neutralize toxins, reduce chlorine levels, and act as a powerful reducing agent. It is often referred to as “hypo” in the field of photography, where it serves as a fixer for developing films and photographs.
Chemical Properties of Sodium Thiosulfate
Understanding the chemical nature of sodium thiosulfate is essential for its wide-scale applications:
Molecular formula: Na₂S₂O₃
Molar mass: 158.11 g/mol (anhydrous), 248.18 g/mol (pentahydrate)
Appearance: Transparent, colorless crystals
Solubility: Highly soluble in water, slightly soluble in alcohol
Melting point: 48 °C (pentahydrate loses water of crystallization)
pH: Neutral to slightly alkaline in solution
One of its most important reactions is with iodine, where it reduces iodine to iodide, making it useful in titrimetric analysis in chemistry.
Preparation method
Sodium thiosulfate is typically prepared through industrial processes, involving the reaction of sodium sulfite with sulfur.
Equation:
Na₂SO₃ + S → Na₂S₂O₃
Another method involves the reaction of sodium hydroxide with sulfur dioxide in the presence of sulfur. These methods ensure large-scale production to meet industrial and medical demand.
Uses of Sodium Thiosulfate
Sodium thiosulfate has numerous applications due to its chemical reactivity and safety profile. Some of the most important uses include:
1. Medical Applications
Used as an antidote for cyanide poisoning by converting toxic cyanide into harmless thiocyanate, which is excreted through urine.
Employed in the treatment of calciphylaxis, a rare but serious condition in patients with chronic kidney disease.
Acts as a chelating agent to detoxify the body from heavy metals like arsenic and mercury.
Sometimes used in dermatology to treat fungal skin infections.
2. Water Treatment
Neutralizes excess chlorine in drinking water and swimming pools.
Removes residual disinfectants after water treatment processes.
Plays a role in aquarium maintenance by detoxifying harmful chlorine and chloramine.
3. Analytical Chemistry
Widely used in iodometric titrations due to its reducing property.
Helps determine the amount of oxidizing agents present in a solution.
4. Industrial Applications
Functions as a fixer in photography, stabilizing photographic images by dissolving unreacted silver halide.
Utilized in the leaching of gold and silver in mining industries.
Serves as a dechlorinating agent in the textile and paper industries.
Prevents bleaching damage in fabrics during processing.
5. Food Industry
It acts as a preservative and helps neutralize excess chlorine in food processing.
Benefits of Sodium Thiosulfate
Versatility: Its ability to act as a reducing, detoxifying, and stabilizing agent makes it valuable across sectors.
Safety: Compared to many chemicals, sodium thiosulfate has a relatively low toxicity profile when used correctly.
Cost-Effectiveness: Its wide availability and affordability make it a preferred choice in industries.
Medical Importance: Life-saving in cases of poisoning and kidney-related complications.
Health and Safety Considerations
While It is generally safe, it should be handled with care:
Inhalation: Dust may cause mild irritation of the respiratory tract.
Skin contact: Can cause slight irritation in sensitive individuals.
Ingestion: Considered safe in medical doses but may lead to gastrointestinal discomfort if consumed in large amounts.
Storage: Keep in a cool, dry place away from moisture and strong acids.
Always follow standard laboratory safety guidelines and consult a professional before using sodium thiosulfate for medical purposes.
Environmental Impact
It is relatively safe for the environment:
Helps in neutralizing harmful chemicals in wastewater.
Used in aquariums to make water safe for fish.
Biodegradable and breaks down into harmless byproducts.
However, large uncontrolled releases into water systems should be avoided to maintain ecological balance.
Conclusion
It is a multi-functional chemical with profound importance in medicine, industry, water treatment, and environmental safety. Its unique ability to detoxify, reduce, and stabilize makes it indispensable in modern science and technology. From saving lives in medical emergencies to purifying drinking water and preserving photographs, sodium thiosulfate stands out as a compound of immense value.
What is sodium thiosulfate used for?
Is sodium thiosulfate safe for humans?
How does sodium thiosulfate treat cyanide poisoning?
Can sodium thiosulfate be used in aquariums?
Is sodium thiosulfate the same as hypo?
What is sodium thiosulfate used for?
Introduction to Sodium Thiosulfate
Sodium thiosulfate is an inorganic salt composed of sodium, sulfur, and oxygen. It commonly appears as colorless, odorless crystals that dissolve easily in water. Its pentahydrate form (Na₂S₂O₃·5H₂O) is the most stable and widely used.
This compound is known for its ability to neutralize toxins, reduce chlorine levels, and act as a powerful reducing agent. It is often referred to as “hypo” in the field of photography, where it serves as a fixer for developing films and photographs.
Chemical Properties of Sodium Thiosulfate
Understanding the chemical nature of sodium thiosulfate is essential for its wide-scale applications:
Molecular formula: Na₂S₂O₃
Molar mass: 158.11 g/mol (anhydrous), 248.18 g/mol (pentahydrate)
Appearance: Transparent, colorless crystals
Solubility: Highly soluble in water, slightly soluble in alcohol
Melting point: 48 °C (pentahydrate loses water of crystallization)
pH: Neutral to slightly alkaline in solution
One of its most important reactions is with iodine, where it reduces iodine to iodide, making it useful in titrimetric analysis in chemistry.
Preparation method
Sodium thiosulfate is typically prepared through industrial processes, involving the reaction of sodium sulfite with sulfur.
Equation:
Na₂SO₃ + S → Na₂S₂O₃
Another method involves the reaction of sodium hydroxide with sulfur dioxide in the presence of sulfur. These methods ensure large-scale production to meet industrial and medical demand.
Uses of Sodium Thiosulfate
Sodium thiosulfate has numerous applications due to its chemical reactivity and safety profile. Some of the most important uses include:
1. Medical Applications
Used as an antidote for cyanide poisoning by converting toxic cyanide into harmless thiocyanate, which is excreted through urine.
Employed in the treatment of calciphylaxis, a rare but serious condition in patients with chronic kidney disease.
Acts as a chelating agent to detoxify the body from heavy metals like arsenic and mercury.
Sometimes used in dermatology to treat fungal skin infections.
2. Water Treatment
Neutralizes excess chlorine in drinking water and swimming pools.
Removes residual disinfectants after water treatment processes.
Plays a role in aquarium maintenance by detoxifying harmful chlorine and chloramine.
3. Analytical Chemistry
Widely used in iodometric titrations due to its reducing property.
Helps determine the amount of oxidizing agents present in a solution.
4. Industrial Applications
Functions as a fixer in photography, stabilizing photographic images by dissolving unreacted silver halide.
Utilized in the leaching of gold and silver in mining industries.
Serves as a dechlorinating agent in the textile and paper industries.
Prevents bleaching damage in fabrics during processing.
5. Food Industry
It acts as a preservative and helps neutralize excess chlorine in food processing.
Benefits of Sodium Thiosulfate
Versatility: Its ability to act as a reducing, detoxifying, and stabilizing agent makes it valuable across sectors.
Safety: Compared to many chemicals, sodium thiosulfate has a relatively low toxicity profile when used correctly.
Cost-Effectiveness: Its wide availability and affordability make it a preferred choice in industries.
Medical Importance: Life-saving in cases of poisoning and kidney-related complications.
Health and Safety Considerations
While It is generally safe, it should be handled with care:
Inhalation: Dust may cause mild irritation of the respiratory tract.
Skin contact: Can cause slight irritation in sensitive individuals.
Ingestion: Considered safe in medical doses but may lead to gastrointestinal discomfort if consumed in large amounts.
Storage: Keep in a cool, dry place away from moisture and strong acids.
Always follow standard laboratory safety guidelines and consult a professional before using sodium thiosulfate for medical purposes.
Environmental Impact
It is relatively safe for the environment:
Helps in neutralizing harmful chemicals in wastewater.
Used in aquariums to make water safe for fish.
Biodegradable and breaks down into harmless byproducts.
However, large uncontrolled releases into water systems should be avoided to maintain ecological balance.
Conclusion
It is a multi-functional chemical with profound importance in medicine, industry, water treatment, and environmental safety. Its unique ability to detoxify, reduce, and stabilize makes it indispensable in modern science and technology. From saving lives in medical emergencies to purifying drinking water and preserving photographs, sodium thiosulfate stands out as a compound of immense value.
Write the uses of Sodium thiosulfate.
Sodium thiosulfate has numerous applications due to its chemical reactivity and safety profile. Some of the most important uses include:
1. Medical Applications
Used as an antidote for cyanide poisoning by converting toxic cyanide into harmless thiocyanate, which is excreted through urine.
Employed in the treatment of calciphylaxis, a rare but serious condition in patients with chronic kidney disease.
Acts as a chelating agent to detoxify the body from heavy metals like arsenic and mercury.
Sometimes used in dermatology to treat fungal skin infections.
2. Water Treatment
Neutralizes excess chlorine in drinking water and swimming pools.
Removes residual disinfectants after water treatment processes.
Plays a role in aquarium maintenance by detoxifying harmful chlorine and chloramine.
3. Analytical Chemistry
Widely used in iodometric titrations due to its reducing property.
Helps determine the amount of oxidizing agents present in a solution.
4. Industrial Applications
Functions as a fixer in photography, stabilizing photographic images by dissolving unreacted silver halide.
Utilized in the leaching of gold and silver in mining industries.
Serves as a dechlorinating agent in the textile and paper industries.
Prevents bleaching damage in fabrics during processing.
5. Food Industry
It acts as a preservative and helps neutralize excess chlorine in food processing.
Benefits of Sodium Thiosulfate
Versatility: Its ability to act as a reducing, detoxifying, and stabilizing agent makes it valuable across sectors.
Safety: Compared to many chemicals, sodium thiosulfate has a relatively low toxicity profile when used correctly.
Cost-Effectiveness: Its wide availability and affordability make it a preferred choice in industries.
Medical Importance: Life-saving in cases of poisoning and kidney-related complications.
Health and Safety Considerations
While It is generally safe, it should be handled with care:
Inhalation: Dust may cause mild irritation of the respiratory tract.
Skin contact: Can cause slight irritation in sensitive individuals.
Ingestion: Considered safe in medical doses but may lead to gastrointestinal discomfort if consumed in large amounts.
Storage: Keep in a cool, dry place away from moisture and strong acids.
Always follow standard laboratory safety guidelines and consult a professional before using sodium thiosulfate for medical purposes.
Environmental Impact
It is relatively safe for the environment:
Helps in neutralizing harmful chemicals in wastewater.
Used in aquariums to make water safe for fish.
Biodegradable and breaks down into harmless byproducts.
However, large uncontrolled releases into water systems should be avoided to maintain ecological balance.
Conclusion
It is a multi-functional chemical with profound importance in medicine, industry, water treatment, and environmental safety. Its unique ability to detoxify, reduce, and stabilize makes it indispensable in modern science and technology. From saving lives in medical emergencies to purifying drinking water and preserving photographs, sodium thiosulfate stands out as a compound of immense value.